Rams at 49ers Game Center

Rams quarterback Matthew Stafford threw for 280 yards and four touchdowns against the 49ers in Week 10.

Watch as Los Angeles Rams head coach Sean McVay hands a game ball to quarterback Matthew Stafford after Sunday's Week 10 win over the San Francisco 49ers.

Watch the best plays from Los Angeles Rams quarterback Matthew Stafford's four-touchdown game against the San Francisco 49ers in Week 10 of the 2025 NFL season.

The Los Angeles Rams take on the San Francisco 49ers for Week 10 at Levi's Stadium. Take a look at photos from the matchup!

Rams wide receiver Davante Adams' 112th career receiving touchdown puts him ahead of Tony Gonzalez for 8th all-time.

Watch the best plays by the Los Angeles Rams against the San Francisco 49ers in Week 10 of the 2025 NFL season.

Rams head coach Sean McVay, quarterback Matthew Stafford, wide receiver Davante Adams and cornerback Emmanuel Forbes Jr. spoke with the media after the team's 42-26 win over 49ers.

Los Angeles Rams head coach Sean McVay quarterback Matthew Stafford, wide receiver Davante Adams, and cornerback Emmanuel Forbes Jr. talk about the Rams' key plays from their Week 10 win over the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams head coach Sean McVay quarterback Matthew Stafford, wide receiver Davante Adams, and cornerback Emmanuel Forbes Jr. talk about the Rams' key plays from their Week 10 victory over the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams tight end Davis Allen, inside linebacker Nate Landman, wide receiver Puka Nacua, running back Kyren Williams, and cornerback Emmanuel Forbes Jr. look back on their standout plays from the Rams' win over the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams tight end Davis Allen, inside linebacker Nate Landman, wide receiver Puka Nacua, running back Kyren Williams, and cornerback Emmanuel Forbes Jr. look back on their standout plays from the Rams' win over the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams running back Kyren Williams rushes for a 7-yard touchdown against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams outside linebacker Jared Verse blocks an extra-point against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams quarterback Matthew Stafford passes a 16-yard touchdown to tight end Colby Parkinson against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams cornerback Emmanuel Forbes scoops up a deflected pass from San Francisco 49ers quarterback Mac Jones for an interception at Levi's Stadium.

Los Angeles Rams quarterback Matthew Stafford fires a 32-yard ball to tight end Terrance Ferguson in San Francisco 49ers territory at Levi's Stadium.

Los Angeles Rams wide receiver Davante Adams catches a 2-yard touchdown against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams outside linebacker Byron Young trips San Francisco 49ers running back Christian McCaffrey for a fourth-down stop at Levi's Stadium.

Los Angeles Rams quarterback Matthew Stafford darts a 15-yard pass to wide receiver Davante Adams against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams quarterback Matthew Stafford sends his 400th career touchdown pass into the hands of tight end Davis Allen against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams running back Blake Corum rushes for 15 yards against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams wide receiver Puka Nacua reels in a pass from quarterback Matthew Stafford for 15 yards against the San Francisco 49ers at Levi's Stadium.

Los Angeles Rams linebacker Nate Landman peanut punches the ball loose from San Francisco 49ers wide receiver Juan Jennings for a turnover at Levi's Stadium.

Rams quarterback Matthew Stafford has now thrown for 400 career touchdowns across regular season games. 

Los Angeles Rams quarterback Matthew Stafford darts a 23-yard pass to wide receiver Davante Adams against the San Francisco 49ers at Levi's Stadium.